Melatonin is a hormone produced by the pineal gland, a small gland in the brain, which plays a role in the body’s sleep cycles. The brain makes this neurohormone from the amino acid tryptophan. Very small amounts of melatonin are found in foods, although the amount that the diet contributes to the levels of melatonin in the body is not clear.
What you need to know before taking melatonin
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is produced mainly by the pineal gland, located behind the third ventricle in the brain. In the synthesis of melatonin, tryptophan is hydroxy 5-hydroxytryptophan, which in turn is 5-hydroxytryptamine (serotonin). Serotonin becomes the precursor of melatonin and metabolite serotonin by the enzyme n-acetyl-n transferase.
Approximately 90 percent of melatonin is erased in a single passage through the liver. A small proportion of unmetabolized melatonin is also excreted in the urine. Commercially available melatonin can be isolated from the pineal glands of beef or chemically synthesized.
Melatonin has been used to adjust the circadian system in people with jet lag, shift work, delayed sleep phase syndrome, and some older people sleep problems. There is no long-term safety data for this reason if you want to take melatonin longer than indicated, consult your specialist physician to avoid side effects.
As a sleeping aid
Melatonin quick-action sleeping aid promotes rapid absorption and sets normal sleep patterns to promote a more restful, relaxing sleep and better overall health.
The evidence suggests that melatonin is effective in the treatment of most secondary sleep disorders with short-term use. There is evidence suggesting that melatonin is effective in relieving the altered aspect of jet lag sleep and shift work. The evidence suggests that melatonin is safe with short-term use. Exogenous melatonin has a short half-life and penetrates the brain barrier and has a link between endogenous melatonin and the sleep cycle.
Read the label
The pharmacy label on your melatonin drug tells you how much medicine to take. It also tells you how often to take your melatonin medicine.
The dose of melatonin is the one that you and your doctor have agreed to take. You should not change the dosage of your medicine unless you are told to do so by your doctor.
If you feel the medication is doing wrong or you do not think you are working, then talk to your doctor to identify what the problem is.
Reasonable usage of melatonin
Melatonin is not suitable for everyone and some people should never use it. Other people should only buy melatonin with special care. It is important that the person who prescribes this medication knows his or her complete medical history.
Your doctor may prescribe only this medication with special care or you may not prescribe that at all if you are under 55 years of age. You are allergic or sensitive or have had a reaction to any of the ingredients in the medicine. Having an auto-immune problem has kidney problems. He’s got liver problems.
As part of the evaluation process of suitability for taking melatonin you can also organize some tests: to check that taking melatonin is not having unwanted effects.
Over time it is possible that melatonin may become inadequate for some people. If at any time, melatonin seems to be adequate, it is important to consult the doctor immediately.
Melatonin supplements may affect your ability to drive or operate machinery.
You should see how melatonin affects your system before judging whether you are sure you are driving or handling machinery. If you have any questions about whether to drive or handle machinery when you buy melatonin uk consult with your doctor on which brand and dosage is best for you.
Melatonin and pregnancy
The use of melatonin is not recommended during pregnancy. You should only take a melatonin supplement during pregnancy if your doctor thinks you need it.
If you are taking melatonin supplements and are planning to have a baby, you should contact your doctor.
You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together they can decide about the treatment you may need during your pregnancy.
You should discuss whether there are other medications you could take during pregnancy than treat your condition.